Switching Reference Medicines to Biosimilars: A Systematic Literature Review of Clinical Outcomes.

ABSTRACT:

Introduction

To evaluate the possibility that switching from reference biologic medicines to biosimilars could lead to altered clinical outcomes, including enhanced immunogenicity, compromised safety, or diminished efficacy for patients, a systematic literature review was conducted of all switching studies between related biologics (including biosimilars).

Methods

A systematic search was conducted using the Medline^® and Embase^® databases up to 30 June 2017 employing specific medical subject heading terms. Additionally, the snowball method and a hand search were also applied. Publications were considered if they contained efficacy or safety information related to a switch from a reference medicine to a biosimilar. Non-English, non-human studies, editoria

SUBMITTER: Cohen HP 

PROVIDER: S-EPMC5854749 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature