Singular Location and Signaling Profile of Adenosine A_2A-Cannabinoid CB₁ Receptor Heteromers in the Dorsal Striatum.

ABSTRACT: The dorsal striatum is a key node for many neurobiological processes such as motor activity, cognitive functions, and affective processes. The proper functioning of striatal neurons relies critically on metabotropic receptors. Specifically, the main adenosine and endocannabinoid receptors present in the striatum, ie, adenosine A_2A receptor (A_2AR) and cannabinoid CB₁ receptor (CB₁R), are of pivotal importance in the control of neuronal excitability. Facilitatory and inhibitory functional interactions between striatal A_2AR and CB₁R have been reported, and evidence supports that this cross-talk may rely, at least in part, on the formation of A_2AR-CB₁R heteromeric complexes. However, the specific location a

SUBMITTER: Moreno E 

PROVIDER: S-EPMC5854787 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature