Oxygen Activation and Radical Transformations in Heme Proteins and Metalloporphyrins.

ABSTRACT: As a result of the adaptation of life to an aerobic environment, nature has evolved a panoply of metalloproteins for oxidative metabolism and protection against reactive oxygen species. Despite the diverse structures and functions of these proteins, they share common mechanistic grounds. An open-shell transition metal like iron or copper is employed to interact with O₂ and its derived intermediates such as hydrogen peroxide to afford a variety of metal-oxygen intermediates. These reactive intermediates, including metal-superoxo, -(hydro)peroxo, and high-valent metal-oxo species, are the basis for the various biological functions of O₂-utilizing metalloproteins. Collectively, these processes are called oxygen activation. Much of our understanding of the reactivity of t

SUBMITTER: Huang X 

PROVIDER: S-EPMC5855008 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature