Bacterial Dissemination to the Brain in Sepsis.

ABSTRACT:

Rationale

Sepsis causes brain dysfunction and neuroinflammation. It is unknown whether neuroinflammation in sepsis is initiated by dissemination of bacteria to the brain and sustained by persistent infection, or whether neuroinflammation is a sterile process resulting solely from circulating inflammatory mediators.

Objectives

To determine if gut bacteria translocate to the brain during sepsis, and are associated with neuroinflammation.

Methods

Murine sepsis was induced using cecal ligation and puncture, and sepsis survivor mice were compared with sham and unoperated control animals. Brain tissue of patients who died of sepsis was compared with patients who died of noninfectious causes. Bacterial taxa were characterized by 16S ribosomal RNA gene sequencing in both muri

SUBMITTER: Singer BH 

PROVIDER: S-EPMC5855074 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature