Time-dependent risks of cancer clustering among couples: a nationwide population-based cohort study in Taiwan.

ABSTRACT: OBJECTIVES:Spousal clustering of cancer warrants attention. Whether the common environment or high-age vulnerability determines cancer clustering is unclear. The risk of clustering in couples versus non-couples is undetermined. The time to cancer clustering after the first cancer diagnosis is yet to be reported. This study investigated cancer clustering over time among couples by using nationwide data. METHODS:A cohort of 5643 married couples in the 2002-2013 Taiwan National Health Insurance Research Database was identified and randomly matched with 5643 non-couple pairs through dual propensity score matching. Factors associated with clustering (both spouses with tumours) were analysed by using the Cox proportional hazard model. RESULTS:Propensity-matched analysis revealed that the risk of

SUBMITTER: Wang JY 

PROVIDER: S-EPMC5855235 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature