Long-term incidence trends of HPV-related cancers, and cases preventable by HPV vaccination: a registry-based study in Norway.

ABSTRACT: OBJECTIVES:Examine long-term incidence trends of human papillomavirus (HPV)-related cancer in Norway, and estimate the number of cancer cases preventable by vaccines against HPV 16/18 or HPV 16/18/31/33/45/52/58. DESIGN:Observational registry-based study. We extracted incident cases of HPV-related cancer during 1953-2015 from the Cancer Registry of Norway. Tumour HPV prevalence estimates from large international meta-analyses or from Norway were used to estimate the protective potential of HPV vaccines. PARTICIPANTS AND SETTING:The Norwegian population. PRIMARY OUTCOME MEASURES:Incidence trend analyses during 1953-2015 for squamous cell carcinoma (SCC) of the cervix, vulva, vagina, oropharynx, anus and penis, and adenocarcinoma of the cervix. Additionally, the number of cancer cases preven

SUBMITTER: Hansen BT 

PROVIDER: S-EPMC5855252 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature