Developmental Changes Within the Genetic Architecture of Social Communication Behavior: A Multivariate Study of Genetic Variance in Unrelated Individuals.

ABSTRACT:

Background

Recent analyses of trait-disorder overlap suggest that psychiatric dimensions may relate to distinct sets of genes that exert maximum influence during different periods of development. This includes analyses of social communication difficulties that share, depending on their developmental stage, stronger genetic links with either autism spectrum disorder or schizophrenia. We developed a multivariate analysis framework in unrelated individuals to model directly the developmental profile of genetic influences contributing to complex traits, such as social communication difficulties, during an approximately 10-year period spanning childhood and adolescence.

Methods

Longitudinally assessed quantitative social communication problems (N ≤ 5551) were studied in participa

SUBMITTER: St Pourcain B 

PROVIDER: S-EPMC5855319 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature