Effects of five types of selenium supplementation for treatment of Kashin-Beck disease in children: a systematic review and network meta-analysis.

ABSTRACT:

Objective

To compare the effectiveness of five kinds of selenium supplementation for the treatment of patients with Kashin-Beck disease, and rank these selenium supplementations based on their performance.

Design

We searched for all publications between 1 January 1966 and 31 March 2017 using seven electronic databases. GRADE system to network meta-analyses (NMAs) was applied to rate the quality of the evidence. We conducted a random effects model NMA in STATA 12.1 to determine comparative effectiveness of each intervention. Rankings were obtained by using the surface under the cumulative ranking curve (SUCRA) values and mean ranks.

Results

A total of 15 randomised controlled trials involving 2931 patients were included. After assessment of the overall quality of the e

SUBMITTER: Xie D 

PROVIDER: S-EPMC5855457 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature