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Role of Galectins in Tumors and in Clinical Immunotherapy.

ABSTRACT: Galectins are glycan-binding proteins that contain one or two carbohydrate domains and mediate multiple biological functions. By analyzing clinical tumor samples, the abnormal expression of galectins is known to be linked to the development, progression and metastasis of cancers. Galectins also have diverse functions on different immune cells that either promote inflammation or dampen T cell-mediated immune responses, depending on cognate receptors on target cells. Thus, tumor-derived galectins can have bifunctional effects on tumor and immune cells. This review focuses on the biological effects of galectin-1, galectin-3 and galectin-9 in various cancers and discusses anticancer therapies that target these molecules.

SUBMITTER: Chou FC

PROVIDER: S-EPMC5855652 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Role of Galectins in Tumors and in Clinical Immunotherapy.

Chou Feng-Cheng FC Chen Heng-Yi HY Kuo Chih-Chi CC Sytwu Huey-Kang HK

International journal of molecular sciences 20180201 2

Galectins are glycan-binding proteins that contain one or two carbohydrate domains and mediate multiple biological functions. By analyzing clinical tumor samples, the abnormal expression of galectins is known to be linked to the development, progression and metastasis of cancers. Galectins also have diverse functions on different immune cells that either promote inflammation or dampen T cell-mediated immune responses, depending on cognate receptors on target cells. Thus, tumor-derived galectins ...[more]

PMID: 29389859

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