Rings and Bricks: Expression of Cohesin Components is Dynamic during Development and Adult Life.

ABSTRACT: Cohesin complex components exert fundamental roles in animal cells, both canonical in cell cycle and non-canonical in gene expression regulation. Germline mutations in genes coding for cohesins result in developmental disorders named cohesinopaties, of which Cornelia de Lange syndrome (CdLS) is the best-known entity. However, a basic description of mammalian expression pattern of cohesins in a physiologic condition is still needed. Hence, we report a detailed analysis of expression in murine and human tissues of cohesin genes defective in CdLS. Using both quantitative and qualitative methods in fetal and adult tissues, cohesin genes were found to be ubiquitously and differentially expressed in human tissues. In particular, abundant expression was observed in hematopoietic and central nervo

SUBMITTER: Bettini LR 

PROVIDER: S-EPMC5855660 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature