Role of Corneal Stromal Cells on Epithelial Cell Function during Wound Healing.

ABSTRACT: Following injury, corneal stromal keratocytes transform into repair-phenotype of activated stromal fibroblasts (SFs) and participate in wound repair. Simultaneously, ongoing bi-directional communications between corneal stromal-epithelial cells also play a vital role in mediating the process of wound healing. Factors produced by stromal cells are known to induce proliferation, differentiation, and motility of corneal epithelial cells, which are also subsequently the main processes that occur during wound healing. In this context, the present study aims to investigate the effect of SFs conditioned medium (SFCM) on corneal epithelial cell function along with substance P (SP). Antibody microarrays were employed to profile differentially expressed cell surface markers and cytokines in the pres

SUBMITTER: Kowtharapu BS 

PROVIDER: S-EPMC5855686 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature