Prediction of Effective Drug Combinations by an Improved Naive Bayesian Algorithm.

ABSTRACT: Drug combinatorial therapy is a promising strategy for combating complex diseases due to its fewer side effects, lower toxicity and better efficacy. However, it is not feasible to determine all the effective drug combinations in the vast space of possible combinations given the increasing number of approved drugs in the market, since the experimental methods for identification of effective drug combinations are both labor- and time-consuming. In this study, we conducted systematic analysis of various types of features to characterize pairs of drugs. These features included information about the targets of the drugs, the pathway in which the target protein of a drug was involved in, side effects of drugs, metabolic enzymes of the drugs, and drug transporters. The latter two features (metabo

SUBMITTER: Bai LY 

PROVIDER: S-EPMC5855689 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature