MiRNA as a New Regulatory Mechanism of Estrogen Vascular Action.

ABSTRACT: The beneficial effects of estrogen on the cardiovascular system have been reported extensively. In fact, the incidence of cardiovascular diseases in women is lower than in age-matched men during their fertile stage of life, a benefit that disappears after menopause. These sex-related differences point to sexual hormones, mainly estrogen, as possible cardiovascular protective factors. The regulation of vascular function by estrogen is mainly related to the maintenance of normal endothelial function and is mediated by both direct and indirect gene transcription through the activity of specific estrogen receptors. Some of these mechanisms are known, but many remain to be elucidated. In recent years, microRNAs have been established as non-coding RNAs that regulate the expression of a high perc

SUBMITTER: Perez-Cremades D 

PROVIDER: S-EPMC5855695 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature