Interventional Left Atrial Appendage Closure Affects the Metabolism of Acylcarnitines.

ABSTRACT:

Background

Left atrial appendage closure (LAAC) represents the interventional alternative to oral anticoagulation for stroke prevention in atrial fibrillation (AF). The metabolism of acylcarnitines was shown to affect cardiovascular diseases. This study evaluates the influence of successful LAAC on the metabolism of acylcarnitines.

Methods

Patients undergoing successful LAAC were enrolled prospectively. Peripheral blood samples for metabolomics measurements were collected immediately before (i.e., index) and six months after LAAC (i.e., mid-term). A targeted metabolomics analysis based on electrospray ionization-liquid chromatography-mass spectrometry (ESI-LC-MS/MS) and MS/MS measurements was performed.

Results

44 patients with non-valvular AF (median CHA₂DS₂-VASc sco

SUBMITTER: Fastner C 

PROVIDER: S-EPMC5855722 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature