Genome-Wide Identification and Characterization of WD40 Protein Genes in the Silkworm, Bombyx mori.

ABSTRACT: WD40 proteins are scaffolding molecules in protein-protein interactions and play crucial roles in fundamental biological processes. Genome-wide characterization of WD40 proteins in animals has been conducted solely in humans. We retrieved 172 WD40 protein genes in silkworm (BmWD40s) and identified these genes in 7 other insects, 9 vertebrates and 5 nematodes. Comparative analysis revealed that the WD40 protein gene family underwent lineage-specific expansions during animal evolution, but did not undergo significant expansion during insect evolution. The BmWD40s were categorized into five clusters and 12 classes according to the phylogenetic classification and their domain architectures, respectively. Sequence analyses indicated that tandem and segmental duplication played min

SUBMITTER: He S 

PROVIDER: S-EPMC5855749 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature