Association of genetic variation in COMT gene with pain related to sickle cell disease in patients from the walk-PHaSST study.

ABSTRACT:

Background

Vaso-occlusive pain episodes (VOEs) are the hallmark of sickle cell disease (SCD), and our current understanding of disease biology, treatment, and psychological covariates does not adequately explain the variability of pain in SCD. Functional variants in catechol-O-methyltransferase (COMT) gene contribute to variability in pain perception, but their impact on pain perception in African American SCD patients is not well known.

Methods

We studied COMT single-nucleotide polymorphisms (SNPs) rs6269, rs4633, rs4818, rs4680, and rs165599 to determine their relationship to patient self-reported pain, the number of acute VOEs, and their impact on daily life and health care utilization in 438 hemoglobin SS patients who participated in the walk-PHaSST

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5856032 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature