Integration of pharmacology, molecular pathology, and population data science to support precision gastrointestinal oncology.

ABSTRACT: Precision medicine has a goal of customizing disease prevention and treatment strategies. Under the precision medicine paradigm, each patient has unique pathologic processes resulting from cellular genomic, epigenomic, proteomic, and metabolomic alterations, which are influenced by pharmacological, environmental, microbial, dietary, and lifestyle factors. Hence, to realize the promise of precision medicine, multi-level research methods that can comprehensively analyze many of these variables are needed. In order to address this gap, the integrative field of molecular pathology and population data science (i.e., molecular pathological epidemiology) has been developed to enable such multi-level analyses, especially in gastrointestinal cancer research. Further integration of pharmacology can

SUBMITTER: Ogino S 

PROVIDER: S-EPMC5856171 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature