Spatial relationship of organized rotational and focal sources in human atrial fibrillation to autonomic ganglionated plexi.

ABSTRACT:

Background

One approach to improve ablation for atrial fibrillation (AF) is to focus on physiological targets including focal or rotational sources or ganglionic plexi (GP). However, the spatial relationship between these potential mechanisms has never been studied. We tested the hypothesis that rotors and focal sources for AF may co-localize with ganglionated plexi (GP).

Methods

We prospectively identified locations of AF rotors and focal sources, and correlated these to GP sites in 97 consecutive patients (age 59.9±11.4, 73% persistent AF). AF was recorded with 64-pole catheters with activation/phase mapping, and related to anatomic GP sites on electroanatomic maps.

Results

AF sources arose in 96/97 (99%) patients for 2.6±1.4 sources per patient (left atrium: 1.7±0.

SUBMITTER: Baykaner T 

PROVIDER: S-EPMC5856175 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature