A randomized trial of phenylephrine infusion versus bolus dosing for nausea and vomiting during Cesarean delivery in obese women.

ABSTRACT:

Purpose

Hypotension is common after spinal anesthesia for Cesarean delivery. It is associated with nausea, vomiting, and fetal acidosis. Previous research on phenylephrine excluded obese subjects. We compared the incidence of intraoperative nausea and vomiting (IONV) in obese patients who received a prophylactic phenylephrine infusion vs those who received bolus dosing for the treatment of spinal-induced hypotension.

Methods

In this multicentre, double-blinded randomized controlled trial, 160 obese women undergoing elective Cesarean delivery under spinal anesthesia were randomized to receive a prophylactic phenylephrine infusion initiated at 50 μg·min^-1 (and titrated according to a predefined algorithm) or 100 μg phenylephrine boluses to treat hypotension. Materna

SUBMITTER: George RB 

PROVIDER: S-EPMC5856192 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature