From somatic variants towards precision oncology: Evidence-driven reporting of treatment options in molecular tumor boards.

ABSTRACT:

Background

A comprehensive understanding of cancer has been furthered with technological improvements and decreasing costs of next-generation sequencing (NGS). However, the complexity of interpreting genomic data is hindering the implementation of high-throughput technologies in the clinical context: increasing evidence on gene-drug interactions complicates the task of assigning clinical significance to genomic variants.

Methods

Here we present a method that automatically matches patient-specific genomic alterations to treatment options. The method relies entirely on public knowledge of somatic variants with predictive evidence on drug response. The output report is aimed at supporting clinicians in the task of finding the clinical meaning of genomic variants. We applied the

SUBMITTER: Perera-Bel J 

PROVIDER: S-EPMC5856211 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature