Modulation of nucleosomal DNA accessibility via charge-altering post-translational modifications in histone core.

ABSTRACT:

Background

Controlled modulation of nucleosomal DNA accessibility via post-translational modifications (PTM) is a critical component to many cellular functions. Charge-altering PTMs in the globular histone core-including acetylation, phosphorylation, crotonylation, propionylation, butyrylation, formylation, and citrullination-can alter the strong electrostatic interactions between the oppositely charged nucleosomal DNA and the histone proteins and thus modulate accessibility of the nucleosomal DNA, affecting processes that depend on access to the genetic information, such as transcription. However, direct experimental investigation of the effects of these PTMs is very difficult. Theoretical models can rationalize existing observations, suggest working hypotheses for future experime

SUBMITTER: Fenley AT 

PROVIDER: S-EPMC5856334 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature