Neurocognitive subtypes in patients with bipolar disorder and their unaffected siblings.

ABSTRACT:

Background

Our previous work revealed substantial heterogeneity in the cognitive profile of bipolar disorder (BD) due to the presence of three underlying cognitive subgroups characterized as: globally impaired, selectively impaired, or cognitively intact. In an effort to determine whether these subgroups are differentially related to genetic risk for the illness, we investigated whether cognitive deficits were more pronounced in unaffected siblings (UAS) of BD probands within identified clusters.

Methods

Cluster analysis was used to identify cognitive clusters in BD (N = 60). UAS (N = 49) were classified into groups according to their proband sibling's cluster assignment; comparisons were made across all clusters and healthy controls (HCs; N = 71).

Results

Three cogni

SUBMITTER: Russo M 

PROVIDER: S-EPMC5856455 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature