Weight change after initiation of oral hypoglycemic monotherapy for diabetes predicts 5-year mortality: An observational study.

ABSTRACT:

Purpose

To investigate whether weight change in the first year after initiating an oral hypoglycemic agent (OHA) for type 2 diabetes treatment is associated with mortality in a national cohort.

Procedures

We prospectively followed Veterans Health Administration patients with type 2 diabetes initiating treatment with an OHA and not receiving any other diabetes pharmacotherapy for at least one year. Information on OHAs, weight, co-morbidities, other medications, demographics, and laboratory measurements was obtained from electronic medical records. Logistic regression was used to estimate 5-year mortality odds by weight change during the first year after OHA treatment initiation.

Findings

Patients (mean age 65years, 97% male, mean BMI 32.3kg/m²) initiating OH

SUBMITTER: Kocarnik BM 

PROVIDER: S-EPMC5856463 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature