Role of a single noncoding nucleotide in the evolution of an epidemic African clade of <i>Salmonella</i>.

ABSTRACT: Salmonella enterica serovar Typhimurium ST313 is a relatively newly emerged sequence type that is causing a devastating epidemic of bloodstream infections across sub-Saharan Africa. Analysis of hundreds of Salmonella genomes has revealed that ST313 is closely related to the ST19 group of S Typhimurium that cause gastroenteritis across the world. The core genomes of ST313 and ST19 vary by only ∼1,000 SNPs. We hypothesized that the phenotypic differences that distinguish African Salmonella from ST19 are caused by certain SNPs that directly modulate the transcription of virulence genes. Here we identified 3,597 transcriptional start sites of the ST313 strain D23580, and searched for a gene-expression signature linked to pathogenesis of Salmonella We identifi

SUBMITTER: Hammarlof DL 

PROVIDER: S-EPMC5856525 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature