Exploring functional pairing between surface glycoconjugates and human galectins using programmable glycodendrimersomes.

ABSTRACT: Precise translation of glycan-encoded information into cellular activity depends critically on highly specific functional pairing between glycans and their human lectin counter receptors. Sulfoglycolipids, such as sulfatides, are important glycolipid components of the biological membranes found in the nervous and immune systems. The optimal molecular and spatial design aspects of sulfated and nonsulfated glycans with high specificity for lectin-mediated bridging are unknown. To elucidate how different molecular and spatial aspects combine to ensure the high specificity of lectin-mediated bridging, a bottom-up toolbox is devised. To this end, negatively surface-charged glycodendrimersomes (GDSs), of different nanoscale dimensions, containing sulfo-lactose groups are self-assembled in buffer

SUBMITTER: Xiao Q 

PROVIDER: S-EPMC5856548 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature