Expanded cellular clones carrying replication-competent HIV-1 persist, wax, and wane.

ABSTRACT: The latent reservoir for HIV-1 in resting CD4⁺ T cells is a major barrier to cure. Several lines of evidence suggest that the latent reservoir is maintained through cellular proliferation. Analysis of this proliferative process is complicated by the fact that most infected cells carry defective proviruses. Additional complications are that stimuli that drive T cell proliferation can also induce virus production from latently infected cells and productively infected cells have a short in vivo half-life. In this ex vivo study, we show that latently infected cells containing replication-competent HIV-1 can proliferate in response to T cell receptor agonists or cytokines that are known to induce homeostatic proliferation and that this can occur without virus production. Some cells t

SUBMITTER: Wang Z 

PROVIDER: S-EPMC5856552 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature