MLH1-rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques.

ABSTRACT: Over the past two decades, 33 cases of colonic adenocarcinomas have been diagnosed in rhesus macaques (Macaca mulatta) at the nonhuman primate colony of the Keeling Center for Comparative Medicine and Research at The University of Texas MD Anderson Cancer Center. The distinctive feature in these cases, based on PET/computed tomography (CT) imaging, was the presence of two or three tumor lesions in different locations, including proximal to the ileocecal juncture, proximal to the hepatic flexure, and/or in the sigmoid colon. These colon carcinoma lesions selectively accumulated [¹⁸F]fluorodeoxyglucose ([¹⁸F]FDG) and [¹⁸F]fluoroacetate ([¹⁸F]FACE) at high levels, reflecting elevated carbohydrate and fatty acid metabolism in these tumors. In

SUBMITTER: Brammer DW 

PROVIDER: S-EPMC5856559 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature