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Mechanical stretch induced transcriptomic profiles in cardiac myocytes.

ABSTRACT: Mechanical forces are able to activate hypertrophic growth of cardiomyocytes in the overloaded myocardium. However, the transcriptional profiles triggered by mechanical stretch in cardiac myocytes are not fully understood. Here, we performed the first genome-wide time series study of gene expression changes in stretched cultured neonatal rat ventricular myocytes (NRVM)s, resulting in 205, 579, 737, 621, and 1542 differentially expressed (>2-fold, P?

SUBMITTER: Rysa J 

PROVIDER: S-EPMC5856749 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Mechanical stretch induced transcriptomic profiles in cardiac myocytes.

Rysä Jaana J   Tokola Heikki H   Ruskoaho Heikki H  

Scientific reports 20180316 1

Mechanical forces are able to activate hypertrophic growth of cardiomyocytes in the overloaded myocardium. However, the transcriptional profiles triggered by mechanical stretch in cardiac myocytes are not fully understood. Here, we performed the first genome-wide time series study of gene expression changes in stretched cultured neonatal rat ventricular myocytes (NRVM)s, resulting in 205, 579, 737, 621, and 1542 differentially expressed (>2-fold, P < 0.05) genes in response to 1, 4, 12, 24, and  ...[more]

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