Asenapine Treatment in Pediatric Patients with Bipolar I Disorder or Schizophrenia: A Review.

ABSTRACT: Asenapine, administered as a twice-daily (BID) sublingual tablet, is approved in the US as monotherapy for the acute treatment of manic and mixed episodes of bipolar I disorder in children and adolescents aged 10-17 years based on the positive results of one 3-week, double-blind, placebo-controlled study; the recommended dose is 2.5-10 mg BID. Although asenapine has been studied in pediatric patients with schizophrenia, it is not approved for this indication. Asenapine is not approved for pediatric use in bipolar I disorder or schizophrenia in other major markets. To inform clinicians treating psychiatric disorders in pediatric patients, we have summarized the neuropharmacology, pharmacokinetics, clinical trial experience, and clinical use of asenapine in pediatric patients. After rapid ab

SUBMITTER: Stepanova E 

PROVIDER: S-EPMC5856894 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature