CC16 levels correlate with cigarette smoke exposure in bronchial epithelial cells and with lung function decline in smokers.

ABSTRACT: BACKGROUND:Club cell protein-16 (CC16) expression has been associated with smoking-related lung function decline. The study hypothesis was that CC16 expression in both serum and bronchial epithelium is associated with lung function decline in smokers, and exposure to cigarette smoke will lead to reduction in CC16 expression in bronchial epithelial cells. METHODS:In a cohort of community-based male Chinese subjects recruited for lung function test in 2000, we reassessed their lung function ten years later and measured serum levels of CC16. CC16 expression was further assayed in bronchial epithelium from endobronchial biopsies taken from an independent cohort of subjects undergoing autofluorescence bronchoscopy, and tested for correlation between CC16 immunostaining intensity and lung functi

SUBMITTER: Lam DC 

PROVIDER: S-EPMC5857103 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature