An efficient antimicrobial depot for infectious site-targeted chemo-photothermal therapy.

ABSTRACT:

Background

Silver and photothermal therapy (PTT) have been widely used for eradicating the drug-resistant bacteria. However, the risks of excess of silver for humans and the low efficiency of PTT still limit their in vivo therapeutic application. Integration of two distinctive bactericides into one entity is a promising platform to improve the efficiency of antimicrobial agents.

Results

In this study, a chemo-photothermal therapeutic platform based on polydopamine (PDA)-coated gold nanorods (GNRs) was developed. The PDA coating acquired high Ag⁺ ions loading efficiency and Cy5-SE fluorescent agent labeled glycol chitosan (GCS) conjugation (Ag⁺-GCS-PDA@GNRs). This platform became positively charged in the low pH environment of the abscess, allowing their

SUBMITTER: Liu M 

PROVIDER: S-EPMC5857115 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature