Gastric cancer biomarkers; A systems biology approach.

ABSTRACT: Gastric cancer is one of the most fatal cancers in the world. Many efforts in recent years have attempted to find effective proteins in gastric cancer. By using a comprehensive list of proteins involved in gastric cancer, scientists were able to retrieve interaction information. The study of protein-protein interaction networks through systems biology based analysis provides appropriate strategies to discover candidate proteins and key biological pathways. In this study, we investigated dominant functional themes and centrality parameters including betweenness as well as the degree of each topological clusters and expressionally active sub-networks in the resulted network. The results of functional analysis on gene sets showed that neurotrophin signaling pathway, cell cycle and nucleotide

SUBMITTER: Saberi Anvar M 

PROVIDER: S-EPMC5857180 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature