Extracellular matrix hydrogel therapies: In vivo applications and development.

ABSTRACT: Decellularized extracellular matrix (ECM) has been widely used for tissue engineering applications and is becoming increasingly versatile as it can take many forms, including patches, powders, and hydrogels. Following additional processing, decellularized ECM can form an inducible hydrogel that can be injected, providing for new minimally-invasive procedure opportunities. ECM hydrogels have been derived from numerous tissue sources and applied to treat many disease models, such as ischemic injuries and organ regeneration or replacement. This review will focus on in vivo applications of ECM hydrogels and functional outcomes in disease models, as well as discuss considerations for clinical translation.

Statement of significance

Extracellular matrix (ECM) hydrogel therapies are being d

SUBMITTER: Spang MT 

PROVIDER: S-EPMC5857190 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature