Perinatal exposure to concentrated ambient particulates results in autism-like behavioral deficits in adult mice.

ABSTRACT: Exposure to fine ambient particulates (PM_2.5) during gestation or neonatally has potent neurotoxic effects. While biological and behavioral data indicate a vulnerability to environmental pollutants across distinct neurodevelopmental windows, the behavioral consequences following exposure across the entire developmental period remain unknown. Moreover, several epidemiological studies support a link between developmental exposure to air pollution and an increased risk of later receiving a diagnosis of autism spectrum disorders (ASD), a neurodevelopmental disorder that persists throughout life. In the current study we sought to determine whether perinatal exposure to PM_2.5 would reduce sociability and increase repetitive deficits in mice, two hallmark characteristics of

SUBMITTER: Church JS 

PROVIDER: S-EPMC5857220 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature