Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness.

ABSTRACT: Asthma, accompanied by lung inflammation, bronchoconstriction and airway hyper-responsiveness, is a significant public health burden. Here we report that Mas-related G protein-coupled receptors (Mrgprs) are expressed in a subset of vagal sensory neurons innervating the airway and mediates cholinergic bronchoconstriction and airway hyper-responsiveness. These findings provide insights into the neural mechanisms underlying the pathogenesis of asthma.

SUBMITTER: Han L 

PROVIDER: S-EPMC5857222 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature