Mesenchymal Stem Cell Transplantation for Liver Cell Failure: A New Direction and Option.

ABSTRACT:

Background and aims

Mesenchymal stem cell transplantation (MSCT) became available with liver failure (LF), while the advantages of MSCs remain controversial. We aimed to assess clinical advantages of MSCT in patients with LF.

Methods

Clinical researches reporting MSCT in LF patients were searched and included.

Results

Nine articles (n = 476) related with LF patients were enrolled. After MSCT, alanine aminotransferase (ALT) baseline decreased largely at half a month (P < 0.05); total bilirubin (TBIL) baseline declined to a certain stable level of 78.57 μmol/L at 2 and 3 months (P < 0.05). Notably, the decreased value (D value) of Model for End-Stage Liver Disease score (MELD) of acute-on-chronic liver failure (ACLF) group was higher t

SUBMITTER: Cao Y 

PROVIDER: S-EPMC5857323 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature