Preparation, characterization, and in vitro dosimetry of dispersed, engineered nanomaterials.

ABSTRACT: Evidence continues to grow of the importance of in vitro and in vivo dosimetry in the hazard assessment and ranking of engineered nanomaterials (ENMs). Accurate dose metrics are particularly important for in vitro cellular screening to assess the potential health risks or bioactivity of ENMs. To ensure meaningful and reproducible quantification of in vitro dose, with consistent measurement and reporting between laboratories, it is necessary to adopt standardized and integrated methodologies for (i) generation of stable ENM suspensions in cell culture media; (ii) colloidal characterization of suspended ENMs, particularly of properties that determine particle kinetics in an in vitro system (size distribution and formed agglomerate effective density); and (iii) robust numerical fate and trans

SUBMITTER: DeLoid GM 

PROVIDER: S-EPMC5857388 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature