Identification of the antigenic epitopes of maternal autoantibodies in autism spectrum disorders.

ABSTRACT: Several groups have described the presence of fetal brain-reactive maternal autoantibodies in the plasma of some mothers whose children have autism spectrum disorder (ASD). We previously identified seven autoantigens targeted by these maternal autoantibodies, each of which is expressed at significant levels in the developing brain and has demonstrated roles in typical neurodevelopment. To further understand the binding repertoire of the maternal autoantibodies, as well as the presence of any meaningful differences with respect to the recognition and binding of these ASD-specific autoantibodies to each of these neuronal autoantigens, we utilized overlapping peptide microarrays incubated with maternal plasma samples obtained from the Childhood Autism Risk from Genetics and Environment (CHARG

SUBMITTER: Edmiston E 

PROVIDER: S-EPMC5857423 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature