Genome-wide association study for pollinosis identified two novel loci in interleukin (IL)-1B in a Japanese population.

ABSTRACT: The number of pollinosis patients in Japan has significantly increased over the past 20 years. The majority of genome-wide association studies (GWAS) on pollinosis have been conducted in subjects of European descent, with few studies in Japanese populations. The aim of our GWAS was to identify genetic loci associated with self-reported pollinosis in a Japanese population and to understand its molecular background using a combination of single nucleotide polymorphisms (SNPs) and gene- and pathway-based analyses. A total of 731 and 560 individuals who were recruited as participants of the Japan Multi-Institutional Collaborative Cohort Study participated in the discovery and replication phases, respectively. The phenotype of pollinosis was based on the information from a self-administered que

SUBMITTER: Fujii R 

PROVIDER: S-EPMC5857507 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature