Altered regulation of cardiac ankyrin repeat protein in heart failure.

ABSTRACT:

Background

Left ventricular assist devices (LVADs) have revolutionized and improved the care of the sickest heart failure (HF) patients, and it is imperative that they receive appropriate ventricular unloading. Assessing this critical parameter with current methodologies (labs, imaging) is usually suboptimal in this patient population. Hence it is imperative to elucidate the molecular underpinnings involved in ventricular unloading. We have previously identified the cytoskeletal protein βII spectrin as an essential nodal protein involved in post-translational targeting and βII spectrin protein levels are significantly altered in multiple forms of human and animal HF. We therefore hypothesized that the βII spectrin pathway would play a critical role in LVAD remodeling.

Methods

SUBMITTER: Kempton A 

PROVIDER: S-EPMC5857524 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature