Effect of a Histone Demethylase Inhibitor on Equine Herpesvirus-1 Activity In Vitro.

ABSTRACT: Equine herpesvirus type 1 (EHV-1) is a ubiquitous and highly contagious pathogen that causes a range of disease severities with outbreaks of notable economic impact. Given the limitations in immune protection of current vaccines and the limited effectiveness of antiviral drugs on EHV-1 infections in vivo, improved treatment measures are needed to control disease. The use of drugs that alter the epigenetic state of herpes simplex virus genome has been shown to limit viral primary infection and reactivation both in vitro and in vivo. Therefore, we tested the hypothesis that maintaining a repressive epigenetic state on the EHV-1 genome in the host equine cell would decrease viral load during lytic infection. Equine fetal kidney cells (EFKCs) or isolated peripheral blood l

SUBMITTER: Tallmadge RL 

PROVIDER: S-EPMC5857540 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature