Pretransplant IgA-Anti-Beta 2 Glycoprotein I Antibodies As a Predictor of Early Graft Thrombosis after Renal Transplantation in the Clinical Practice: A Multicenter and Prospective Study.

ABSTRACT:

Background

Graft thrombosis is a devastating complication after renal transplantation. We recently described the association of anti-beta-2-glycoprotein-I (IgA-ab2GP1) antibodies with early graft loss mainly caused by thrombosis in a monocenter study.

Methods

Multicenter prospective observational cohort study.

Setting and participants

Seven hundred forty patients from five hospitals of the Spanish Forum Renal Group transplanted from 2000 to 2002 were prospectively followed-up for 10 years.

Outcomes

Early graft loss and graft loss by thrombosis.

Measurements

The presence of IgA anti-B2GP1 antibodies in pretransplant serum was examined using the same methodology in all the patients.

Results

At transplantation, 288 patients were positive for IgA-B2GP

SUBMITTER: Morales JM 

PROVIDER: S-EPMC5857545 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature