Vitamin D in Human Immunodeficiency Virus Infection: Influence on Immunity and Disease.

ABSTRACT: People living with human immunodeficiency virus (HIV) infection typically have hypovitaminosis D, which is linked to a large number of pathologies, including immune disorders and infectious diseases. Vitamin D (VitD) is a key regulator of host defense against infections by activating genes and pathways that enhance innate and adaptive immunity. VitD mediates its biological effects by binding to the Vitamin D receptor (VDR), and activating and regulating multiple cellular pathways. Single nucleotide polymorphisms in genes from those pathways have been associated with protection from HIV-1 infection. High levels of VitD and VDR expression are also associated with natural resistance to HIV-1 infection. Conversely, VitD deficiency is linked to more inflammation and immune activation, low perip

SUBMITTER: Jimenez-Sousa MA 

PROVIDER: S-EPMC5857570 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature