Ontology highlight
ABSTRACT:
SUBMITTER: Lu W
PROVIDER: S-EPMC5857607 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Frontiers in chemistry 20180312
Epigenetic dysfunction has been widely implicated in several diseases especially cancers thus highlights the therapeutic potential for chemical interventions in this field. With rapid development of computational methodologies and high-performance computational resources, computer-aided drug design has emerged as a promising strategy to speed up epigenetic drug discovery. Herein, we make a brief overview of major computational methods reported in the literature including druggability prediction, ...[more]