Genetic Platforms of bla_CTX-M in Carbapenemase-Producing Strains of K. pneumoniae Isolated in Chile.

ABSTRACT: Objective: To elucidate whether the genetic platforms of bla_CTX-M contribute to the phenotypes of multi-drug-resistance (MDR) in the first carbapenemase-producing K. pneumoniae strains isolated in Chile. Method: Twenty-two carbapenemase-producing K. pneumoniae strains isolated from different Chilean patients and hospitals were studied. Their genetic relatedness was assessed by PFGE and MLST. The levels of antibiotic resistance were evaluated by determining the minimum inhibitory concentration of various antimicrobials. In addition, several antibiotic resistance genes of clinical relevance in Chile were investigated. The prevalence, allelic variants, and genetic platforms of bla_CTX-M were determined by PCR and sequencing. Re

SUBMITTER: Carrasco-Anabalon S 

PROVIDER: S-EPMC5857710 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature