Identification of stress responsive genes by studying specific relationships between mRNA and protein abundance.

ABSTRACT: Protein expression is regulated by the production and degradation of mRNAs and proteins but the specifics of their relationship are controversial. Although technological advances have enabled genome-wide and time-series surveys of mRNA and protein abundance, recent studies have shown paradoxical results, with most statistical analyses being limited to linear correlation, or analysis of variance applied separately to mRNA and protein datasets. Here, using recently analyzed genome-wide time-series data, we have developed a statistical analysis framework for identifying which types of genes or biological gene groups have significant correlation between mRNA and protein abundance after accounting for potential time delays. Our framework stratifies all genes in terms of the extent of time delay

SUBMITTER: Morimoto S 

PROVIDER: S-EPMC5857721 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature