Prostaglandin E₂ Inhibits Group 2 Innate Lymphoid Cell Activation and Allergic Airway Inflammation Through E-Prostanoid 4-Cyclic Adenosine Monophosphate Signaling.

ABSTRACT: Evidence is accumulating that group 2 innate lymphoid cells (ILC2) play an important role in allergic airway inflammation by producing a large amount of type 2 cytokines. But it remains poorly understood how its activities are properly controlled in vivo. Here, we demonstrated that prostaglandin E₂ (PGE₂) had a profound inhibitory effect on IL-33-induced ILC2 expansion and IL-5 and IL-13 production in vitro. This effect was mimicked by PGE₁-alcohol but attenuated by ONO-AE3-208, indicating a selective action through the E-prostanoid 4 (EP4) receptor. In the IL-33-induced asthma model, coadministration of PGE₂ or PGE₁-alcohol resulted in diminished IL-5 and IL-13 production, reduced eosinophilia and alleviated lung patholo

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC5857904 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature