Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC5857936 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Chemical science 20171020 12
Pre-existing antibodies can aggravate disease during subsequent infection or vaccination <i>via</i> the mechanism of antibody-dependent enhancement (ADE) of infection. Herein, using dengue virus (DENV) as a model, we present a versatile surface-camouflage strategy to obtain a virus core-calcium phosphate shell hybrid by self-templated biomineralization. The shelled DENV stealthily avoids recognition by pre-existing antibodies under extracellular conditions, resulting in the efficient abrogation ...[more]