Noninvasive measures of brain edema predict outcome in pediatric cerebral malaria.

ABSTRACT:

Background

Increased brain volume (BV) and subsequent herniation are strongly associated with death in pediatric cerebral malaria (PCM), a leading killer of children in developing countries. Accurate noninvasive measures of BV are needed for optimal clinical trial design. Our objectives were to examine the performance of six different magnetic resonance imaging (MRI) BV quantification measures for predicting mortality in PCM and to review the advantages and disadvantages of each method.

Methods

Receiver operator characteristics were generated from BV measures of MRIs of children admitted to an ongoing research project with PCM between 2009 and 2014. Fatal cases were matched to the next available survivor. A total of 78 MRIs of children aged 5 months to 13 years (mean 4.0 yea

SUBMITTER: Kampondeni SD 

PROVIDER: S-EPMC5858047 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature