Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study.

ABSTRACT: The critical contribution of membrane proteins in normal cellular function makes their detailed structure and functional analysis essential. Detergents, amphipathic agents with the ability to maintain membrane proteins in a soluble state in aqueous solution, have key roles in membrane protein manipulation. Structural and functional stability is a prerequisite for biophysical characterization. However, many conventional detergents are limited in their ability to stabilize membrane proteins, making development of novel detergents for membrane protein manipulation an important research area. The architecture of a detergent hydrophobic group, that directly interacts with the hydrophobic segment of membrane proteins, is a key factor in dictating their efficacy for both membrane protein solubili

SUBMITTER: Sadaf A 

PROVIDER: S-EPMC5858085 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature